&Sarcoidosis=Sarcoidosis is a multisystem granulomatous disorder of unknown etiology characterized pathologically by the presence of noncaseating granulomas in involved organs. Musculoskeletal disease is a less common problem. However, joint manifestations may be clinically significant in patients with acute disease. Musculoskeletal manifestations include arthropathy, bone lesion, muscular disease, and vasculitis. Acute sarcoid arthritis may present in isolation or as part of Lofgren's syndrome. The acute polyarthritis usually involves the knees and ankles, and may be mistaken for a reactive arthritis. Different forms of chronic arthritis can occur among patients with sarcoidosis: Nondeforming arthritis with granulomatous synovitis; Jaccoud's type deformity (nonerosive joint deformity); Joint swelling adjacent to a sarcoid bone lesion; Dactylitis (sausage-like swelling of one or more digits). The ankle, knees, and hands are the joints most frequently involved; rarely, the sacroiliac and temporomandibular joints may also be affected. The presence of chronic arthritis is frequently associated with parenchymal pulmonary disease and elevated serum concentrations of angiotensin converting enzyme (ACE).