&Systemic Vasculitis=Systemic Vasculitis (systemic inflammatory disorders) common manifestations: inflammation of blood vessels with structural injury. Ischemic manifestations are defined by the size and type of the blood vessels involved. Organ and tissue damage is usually caused by vascular occlusion. Clinical symptoms: fatigue, weight loss, fever, rash (including palpable purpura), joint inflammation, neuropathy (including foot and/or wrist drop) , pulmonary infiltrates or nodules, sinus or nasal inflammation, kidney inflammation or insufficiency, gastrointestinal or liver inflammation. Lab abnormalities include: elevated ESR, anemia, leukocytosis, thrombocytosis. Large vessel vasculitisÑexamples are giant cell (GCA/Temporal arteritis) and takayasu's arteritis. Medium vessel vasculitis: Polyarteritis nodosa (PAN) and Kawasaki's disease (children).  Small vessel vasculitis: Churg-Strauss (ANCA associated), Wegener's (ANCA associated), HSP (children), and cryoglobulinemia (Hepatitis C, malignancy).