&Amyloidosis=Amyloidosis refers to a variety of chronic inflammatory conditions such as multiple myeloma or long standing uncontrolled RA in which amyloid proteins are abnormally deposited in organs and/or tissues. A protein is described as being amyloid if, due to an alteration in its secondary structure, it takes on a particular aggregated insoluble form similar to the beta-pleated sheet.  Symptoms vary widely depending upon the site of amyloid deposition. Amyloidosis may be inherited or acquired. Direct musculoskeletal manifestations due to amyloid deposition may be associated with AL (primary) and dialysis-related amyloidosis and with a variety of amyloidogenic proteins. In addition, musculoskeletal disorders may be the cause rather than the result of AA amyloidosis. Musculoskeletal manifestations of AL amyloid include muscle weakness and enlargement due to amyloid infiltration (myopathy), disorders of the joints (arthropathy), and lesions of bone (osteopathy). Other manifestations of amyloidosis included trigger finger, flexor tendon contracture, spontaneous tendon rupture and pathological fracture through amyloid bone cysts. Carpal tunnel syndrome, often bilateral, may be caused by amyloid deposition in the wrist compressing median nerve.